Biophysics & Structural Biology
Researchers in the IBMS Biophysics and Structural Biology cluster use the principles of chemistry and physics to study biological molecules and biomolecular systems ranging in complexity from objects on the atomic and molecular scale to larger assemblies such as membranes and organelles. A focus of the program are the dynamics, architecture, and physical properties of biological molecules, with an overall aim of understanding these features in the context of biological function. Researchers in the program use a variety of complementary biophysical, biochemical, and computational techniques, including nuclear magnetic resonance, X-ray crystallography, mass spectrometry, and computational simulations. Students will learn to approach biological and biochemical questions from the perspective of physics and physical chemistry, gaining an appreciation for how fundamental principles impact and ultimately give rise to biology.
Image: Structural model of the hydration and ion atmosphere of a mutagenic dye in the minor groove of DNA. Courtesy of the laboratory of Steve Corcelli.
Contact
Jessica Brown (website>)
Department of Chemistry & Biochemistry
Contact by email
(574) 631-6486
Participating Faculty
Brian BakerChemistry and Biochemistry |
Structural biology and biophysics of recognition and signaling in immunity, cancer, and antibiotic resistance |
Basar BilgicerChemistry and Biochemistry |
Biophysical chemistry and biomolecular drug design |
Jessica BrownChemistry and Biochemistry |
Studies of RNA triple helices using structural and biochemical approaches |
Francis CastellinoChemistry and Biochemistry |
In vitro and in vivo relationships between hemostasis and inflammation |
Patricia L. ClarkChemistry and Biochemistry |
Protein biophysics in living cells |
Steve CorcelliChemistry and Biochemistry |
Theoretical and computational studies of reaction dynamics |
Saurja DasGuptaChemistry and Biochemistry |
RNA structure, function, and evolution, RNA Biology, Origins of life |
Juan Del ValleChemistry and Biochemistry |
Design, chemical synthesis, biological evaluation of modulators of protein-protein interactions, ER stress response inhibitors, non-ribosomal peptide natural products; cancer, neurodegenerative disease, bacterial infections |
Holly GoodsonChemistry and Biochemistry; Biological Sciences |
Molecular and cell biology and biophysics |
Shahriar MobasheryChemistry and Biochemistry |
Bioorganic and biochemistry of antibiotic resistance and cancer metastasis |
Brittany MorganChemistry and Biochemistry |
Targeting RNA-binding proteins to understand structure, function, and dynamics |
Jeffrey PengChemistry and Biochemistry; Physics |
NMR methods and biomolecular dynamics |
Anthony S. SerianniChemistry and Biochemistry |
Biomolecular structure and NMR spectroscopy |
Arnaldo SerranoChemistry and Biochemistry |
Nonlinear spectroscopic studies of protein dynamics |
Zoltan ToroczkaiPhysics |
Network modeling in biochemistry, biophysics, and biology |
Katharine WhiteChemistry and Biochemistry |
Cellular pH dynamics; pH-sensitive mechanisms regulating proteins, pathways, and cancer cell behaviors |
Olaf WiestChemistry and Biochemistry |
Computational drug design |
Jeremiah ZartmanBiological Sciences |
systems biology of organ growth and regeneration; reverse-engineering signaling networks and biophysical mechanisms that regulate cell decisions such as differentiation, proliferation, and apoptosis, as it relates to organogenesis, cancer, and wound healing
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