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Eliminating barriers for advancing biomedical science

The Integrated Biomedical Sciences Graduate Program at the University of Notre Dame is a cross-departmental PhD program for research and training in a range of fields in the biomedical sciences. Scientists across the campus, representing 55 different research groups, are organized into thematic Research and Training Clusters that offer students the opportunity to engage in cutting-edge biomedical research that transcends traditional departmental and disciplinary boundaries. Explore our program here, or download a brochure that describes the key aspects.

Recent News

Hackathons may accelerate scientific discovery, study finds

Author: Brandi Klingerman

Hackathonphoto

In a new study, researchers have shown how hackathons, or other crowdsourcing events, may provide a good strategy for building bridges over the traditional divides of research partnerships and accelerate scientific discovery. Read More

SCReM 2018 Travel Fellowship recipient, Kimberly Curtis, presents at World Congress of Biomechanics

Author: Laurie Gregory

Screm 2018Kimberly Curtis at World Congress of Biomechanics in Dublin, Ireland

In describing her work, SCReM 2018 Travel Fellowship recipient, Kimberly Curtis finds that daily activities, such as walking or running, help bone to maintain a strong and healthy architecture due to its ability to adapt to mechanical loading. Osteocytes are resident cells embedded within the mineralized bone matrix and are able to sense mechanical stimulation and elicit a cellular response to increase bone mass. However, there are various cell types in the bone marrow, some of which are mechanosensitive and contribute to bone formation. In her tissue mechanics lab, they culture cylindrical trabecular bone explants harvested from porcine vertebrae in a custom bioreactor. The bioreactor enables them to mechanically stimulate the marrow independent of the osteocytes residing in the mineralized matrix. Using this system, they were able to detect a significant increase in bone formation in stimulated explants compared to unstimulated explants, indicating that marrow cells are mechanosensitive. They also measured an increase in mechanoregulatory cFos gene expression in stimulated marrow cells. Read More