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Helquist and Wiest receive US patent for HDAC inhibitors

Author: Gene Stowe

Olaf Wiest and Paul Helquist

Professors of chemistry and biochemistry, Paul Helquist and Olaf Wiest, together with Frederick Maxfield of Cornell University have received a U.S. patent for potential treatments for Niemann-Pick Type C (NPC) disease. Patent No. 9,333,222, “Histone deacetylase inhibitors as therapeutic agents for Niemann-Pick Type C Disease,” covers the full class of histone deacetylase inhibitors for the genetic, fatal lysosomal storage disorder and related diseases. Read More

Midwest Ovarian Cancer Coalition Workshop Highlights Research, Treatment and Advocacy

Author: M. Sharon Stack, PhD

2016 Midwest Ovarian Cancer Coalition Workshop Highlights Research, Treatment and Advocacy

Mwocc Baylin And Prazno Web

Over 70 researchers from a dozen universities in the Midwest gathered at Notre Dame for the 3rd Midwest Ovarian Cancer Coalition (MWOCC)* workshop to discuss the latest advances in ovarian cancer research.  With a welcome from Mr. Gene Pranzo, Trustee of conference sponsor The Leo and Anne Albert Charitable Trust, attendees were charged to uphold the wishes of the trust and “do good for humanity”.   The good works of the attendees were highlighted in a speed poster session with 3-slide teasers designed to highlight posters in the evening session.   A Keynote address was given by Dr. Stephen Baylin, Ludwig professor of oncology and medicine, Johns Hopkins University and Sidney Kimmel Comprehensive Cancer Center.  Baylin’s presentation summarized the elegant research from his laboratory and the Van Andel Research Institute – Stand Up to Cancer Epigenetics Dream Team in the area of epigenetic therapy.  New advances suggest the ability to more precisely fine-tune combinations of epigenetic therapy with immunotherapy to provide better outcomes for women with advanced ovarian cancer. 

Mwocc Posters6 Web

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Dive into Notre Dame Research during the Alumni Reunion on June 3

Author: Brandi Klingerman

Notre Dame Research will be participating in the Alumni Association’s Annual Reunion event on the first Friday of June on the third floor of the Main Building. From 9 a.m. to 12 p.m., the dome will be open to tours, where several offices will open their doors to alumni, faculty, staff, and friends of the University. Additionally, other buildings on campus will also be open for tours throughout the day. Read More

Hillebrand Center focuses on training compassionate health care professionals

Author: William G. Gilroy

Hillebrand Center

For Ruth Hillebrand, compassionate health care was both a professional and personal mission. A clinical psychologist in Manhattan, she specialized in treating patients with eating disorders. She also had an intimate knowledge of how compassion on the part of a physician could impact a patient’s treatment and recovery. A physician whom she met once delivered her own terminal diagnosis in a brief, perfunctory, late-night phone call and then hung up. Read More

AD&T-supported researchers improve drug delivery, spur commercial activity

Author: Arnie Phifer

Bilgicer Kiziltepe Sm

A new cancer fighting technology developed by Basar Bilgicer and Tanyel Kiziltepe, two professors with deep ties to the University of Notre Dame’s Advanced Diagnostics & Therapeutics (AD&T) initiative, is making a rapid and exciting transition to a real-world, commercialized product—one that could increase the effectiveness of cancer medications while lessening their toxic effects and improving patients’ quality of life.


The Precision Medicine technology is centered on ligand-targeted liposomes (LTLs), tiny bubble-like particles made from a phospholipid bilayer—the same molecules that comprise cell membranes. Using a new technique developed my Bilgicer, Kiziltepe, and others, the liposomes made by the team are much more consistent compared to the industry standard. This innovative format allows the components to be carefully incorporated during liposome synthesis and, in turn, drastically increases uniformity, which has been a major obstacle to the use of LTLs in personalized healthcare. Read More

Notre Dame Researchers receive Translational Training Awards

Author: Brandi Klingerman

The Indiana Clinical and Translational Sciences Institute (CTSI) awarded pre-doctoral training, post-doctoral training, and young investigator awards in translational research to four Notre Dame researchers. The training awards provide funding for research that is translational in nature, taking advantage of the clinical collaboration. Read More

2016-17 TL1 Postdoctoral Training Award recipients

Author: Jenna Bilinski

The Indiana Clinical and Translational Sciences Institute (ICTSI) recently announced its 2016-17 TL1 Postdoctoral Training Award recipients.   ICTSI was able to fund 5 postdoctoral awards (2 renewals and 3 new awards) this period.  The awards, funded by ICTSI (partially funded by the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences Award, and institutional support) are focused on improving young scientists at the participating universities.  Read More

2016-17 CTSI Young Investigator Training Awards

Author: Jenna Bilinski

2016-17 CTSI Young Investigator Training Awards

The Indiana Clinical and Translational Sciences Institute (ICTSI) recently announced its 2016-17 Young Investigator Training Award recipients.  ICTSI was able to fund 10 Young Investigator Awards (4 renewals and 6 new awards) this period.  The awards, funded by ICTSI (partially funded by the National Institutes of Health, National Center for Advancing Translational Sciences, Clinical and Translational Sciences

Award, Neuroscience Strategic Research Initiative, the IU Department of Medicine and institutional support) are focused on improving young scientists at the participating universities. 


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Using mathematical models to fight the Zika virus

Author: Brandi Klingerman

Aedes aegypti mosquito

New research from the University of Notre Dame will be used to generate maps that provide time-sensitive, mosquito-to-human ratios that determine patterns of mosquito population dynamics for the Zika virus. The model outputs will be available online to provide users with the ability to find reported cases and estimated incidences by location of the virus to improve disease transmission and prevalence forecasts, which is critical to making accurate predictions and translating results into effective public health strategies. Read More

Ara Parseghian Medical Research Fund launches at Notre Dame

Author: Marissa Gebhard

Marcia, Christa and Michael Parseghian, three grandchildren of legendary Notre Dame football coach Ara Parseghian who were diagnosed with Niemann-Pick Type C disease

Building on the partnership that the University of Notre Dame formed with the Ara Parseghian Medical Research Foundation in 2010, the University has now established the Ara Parseghian Medical Research Fund and is moving the administrative functions and granting process of the foundation from Tucson, Arizona, to Notre Dame.

Through this partnership, the Parseghian family will continue their fight to find a cure or treatment for Niemann-Pick Type C (NPC) disease and will continue to help fundraise and support researchers around the world. Read More

Midwest Ovarian Cancer Coalition

Author: Jenna Bilinski

Onthis World Ovarian Cancer Day (May 8), we want survivors to know that dedicated  ovarian cancer researchers  are gathering on May 21&22 at the University of Notre Dame  to share their research findings about ovarian cancer biology.  We  want to build on our basic knowledge and use it to provide women with better treatments and early detection. 

Mwocc Logo 2016


Thanks to the Leo & Anne Albert Charitable Trust for funding and support of our effort— the MidWest Ovarian Cancer Coalition (MWOCC) — of bringing together research groups,  survivors, patient advocates and advocacy groups, with the goal of  “IMPROVING THE UNDERSTANDING OF OVARIAN CANCER FOR ALL WOMEN” and working toward a cure for the disease. 


Originally published by Jenna Bilinski at on May 09, 2016. Read More

A Tissue Bank on the Rise

Author: Jenna Bilinski

"There were only four surgeons participating in the tissue bank when I was hired. Now we have eighteen. My job is not only to protect the patients but get more surgeons on board. I had to knock down many doors which takes time and patience” says Page-Mayberry. One of the main challenges in this position is coordinating with the surgeons and their medical teams to help patients understand the purpose to the tissue bank. “I need the surgeons to understand that there is no extra work for them and I need the patients to understand that it is safe and how their donation can make a huge impact. One of these donations can lead to a cure.”  Read More

Cancer Research:  “no form of wisdom can be left out”

Author: M. Sharon Stack, PhD

Cancer Research:  “no form of wisdom can be left out”


Following the news this spring, it has been gratifying to see the international spotlight turned repeatedly on cancer research.  President Obama’s announcement of a “moonshot” program to cure cancer provides new hope to researchers and cancer patients alike, as the designation of additional resources for basic cancer research has proven time and again to stimulate the technological and scientific advances that lead to better diagnostic tools, imaging agents and therapeutic strategies that ultimately impact patient survival.  Speaking at a Vatican conference, Vice President Biden called upon the scientific and faith communities to collaborate in cancer care and prevention.  For scientists at Harper Cancer Research Institute (HCRI), it is our moral obligation to use our talents and intellectual resources to work together to make a significant impact against cancer. Read More

Ebola Research at Notre Dame, IU South Bend Funded by Indiana CTSI

Author: Brandi Klingerman

Ictsi Logo

The Indiana Clinical and Translational Sciences Institute (CTSI) has provided support for Olaf Wiest, University of Notre Dame professor of chemistry and biochemistry, and Robert Stahelin, Indiana University School of Medicine associate professor of biochemistry and molecular biology and adjunct associate professor of chemistry and biochemistry at Notre Dame, through the Notre Dame-CTSI Project Development Team. Read More

Stacking the deck against ovarian cancer

Author: Brandi Klingerman

Sharon Stack

Nearly 70 percent of ovarian cancer cases are detected after metastasis, which is the development of secondary malignant growths distant from the primary site of cancer. Understanding ovarian cancer metastasis is a research focus of M. Sharon Stack, the Ann F. Dunne & Elizabeth Riley Director of the Harper Cancer Research Institute (HCRI) and Kleiderer-Pezold Professor of Chemistry and Biochemistry at the University of Notre Dame. Read More

Notre Dame Biology student recognized for outstanding contributions to science

Author: Sarah Craig

Diane Choi 250

Graduating Biology major, Diane Choi, is being honored with multiple academic achievement awards as the Class of 2016 prepares for graduation. Choi is the recipient of three major undergraduate awards for her work while a science student at Notre Dame.  

The awards include the Outstanding Biology Student Leader Award from the Department of Biological Sciences recognizing “a senior Biology major who has made outstanding contributions, through leadership and service, to advance the interests of other students in the department;” Read More