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Researchers track perfluorinated chemicals in the body

Author: Jessica Sieff

Graham Peaslee

New research in the journal Environmental Science & Technology Letters shows scientists have developed a method to track perfluorinated alkyl substances (PFAS) in the body. PFAS are potentially toxic chemicals found in stain-resistant products, nonstick cookware, fire-fighting foams and — most recently — fast food wrappers.

For the first time, scientists radiolabeled PFAS with a fluorine isotope used in nuclear medicine to track the accumulation of these chemicals in the mouse models. Some of these chemicals have already been linked to kidney cancer, testicular cancer, low birth weight, hypertension, decreased fertility and thyroid problems. Read More

Tuberculosis: The Disease of Antiquity

Author: Jessica Sieff

Jeff SchoreyJeff Schorey

In the time it takes to read this article, half a dozen people will have died from tuberculosis (TB).

It is a cruel and persistent killer, claiming 1.8 million lives each year, an estimated 200,000 of which are children, according to the World Health Organization (WHO).

Considering the gravity of those numbers, it’s even more alarming to know that many cases go unreported.

“Tuberculosis is the most prevalent infectious disease that the world has seen, based on the number of people infected and the number of resulting fatalities,” said Jeff Schorey, George B. Craig Jr. Professor in the Department of Biological Sciences at the University of Notre Dame. “It is the single leading cause of death by an infectious organism.”

Jeff Schorey, a world-renowned expert with pioneering work on the role of exosomes in infectious diseases, has been studying mycobacterial disease for almost two decades.

World Tuberculosis Day marks the official discovery of Mycobacterium tuberculosis by Dr. Robert Koch on March 24, 1882. But the infectious disease is considered to date back thousands of years. It causes death worldwide, primarily affecting low- and middle-income countries. Pulmonary TB can spread with a cough, infecting anyone in the vicinity. Patients require access to first-line drugs and face a six-month regimen of multiple antibiotics. An incomplete course of antibiotics poses an increased risk for developing multi-drug-resistant TB. Read More

Competition challenges graduate students to explain their research in three minutes

Author: Sue Lister

Shaheen 3MT Finals Click for larger image

Nine University of Notre Dame graduate students will compete for prize money while attempting to explain their research in three minutes during the third annual Shaheen Three Minute Thesis competition on Monday (March 27). Known as 3MT, the goal of the competition is for Ph.D. students from Science, Engineering and Arts and Letters to cultivate the ability to explain their research, including both breadth and significance, in a language appropriate to an audience containing both specialists and non-specialists, all within three minutes.

Notre Dame’s 3MT finals will take place from 4 to 6 p.m. in the Jordan Auditorium in the Mendoza College of Business. A reception will follow the competition, which is free and open to the public.

The competitors will address a live audience and panel of judges with a single static slide accompanying their presentations. In addition to monetary prizes, the Notre Dame students are competing to claim a spot in the Midwestern Association of Graduate Schools 3MT regional competition in Indianapolis on April 7.

Advancing from the College of Science are doctoral candidates Julia Beck from biochemistry, Elizabeth Loughran from integrated biomedical sciences and Read More

WHO's list of Priority Pathogen's and Antibiotic Research in the Warren Center

Author: Richard Taylor

February 28, 2017 – For the first time, the World Health Organization (WHO) published a list of “priority pathogens” which constitute a current and extreme threat to human health. WHO is seeking to promote new efforts in the discovery and development of new antibiotics to address a growing threat of antibiotic resistance.


Research encompassing the fundamental mechanism of antibiotic resistance and bacterial biofilms as well as the discovery of new antibiotics and the development of new tools to aid in their discovery have a rich history at the University of Notre Dame and researchers within the Warren Family Center for Drug Discovery & Development.

Shahriar Mobashery’s team recently published research on the regulation of the peptidoglycan protective layer of Gram-negative bacteria such as Pseudomonas aeruginosa. In collaboration with Mayland Chang, Mobashery also discovered two new classes of antibacterials, the oxadiazoles and quinazolinones. Read More

Expanding new areas of rare disease research at Notre Dame

Author: Chontel Syfox and Tammi Freehling


Coinciding with the World Rare Disease Day, Notre Dame acknowledges a recent, generous gift from Notre Dame parents David and Cathleen Reisenauer of Morgan Hill, Calif., which will allow the Warren Family Research Center for Drug Discovery and Development to initiate a new area of research, focusing on the rare disease glycogen storage disease type III (GSDIII), also known as Cori Disease. Read More

Finalists Named in Hotly Contested Shaheen 3MTĀ® Science Qualifying Round

Author: Aaron Bell

2017 Science Finalists 69k jpg Left to right: Finalists Julia Beck, Elizabeth Loughran and Stefan Freed

The College of Science Shaheen 3MT competition began with a big bang on Monday in Jordan Hall of Science.

Julia Beck (Biochemistry), Elizabeth Loughran (Integrated Biomedical Sciences), and Stefan Freed (Biological Sciences) took the top three spots, and will go on to compete at the Shaheen 3MT® Final event on March 23. There they will face 6 as yet to be crowned College of Engineering and College of Arts and Letters. finalists. Read More