Irregular expressions of a panel of regulatory microRNAs (miRNA) in blood and other physiological fluids may allow early screening of many kinds of cancer. However,  the current technologies for identifying and quantifying small numbers of these short (22 bases) molecules in physiological samples require expensive instrumentation and extensive personnel. These...

Cancer’s origin point—a human gene gone haywire—is, in many cases, also its weak spot. If you could block the abnormal function of a gene that is important for metastasis, the theory goes, then maybe you can stop cancer from spreading. But there’s a catch—hit the weak spot with too much...

University of Notre Dame researchers have, for the first time, identified the enzymes that are detrimental to diabetic wound healing and those that are beneficial to repair the wound. There are currently no therapeutics for diabetic wound healing. The current standard of care is palliative to keep the wound clean...

A paper published in a special edition of the journal Science proposes a novel understanding of brain architecture using a network representation of connections within the primate cortex. Zoltán Toroczkai, professor of physics at the University of Notre Dame and co-director of the Interdisciplinary Center for Network Science and Applications,...

The Indiana Clinical and Translational Sciences Institute, which includes the University of Notre Dame as a member, has received a nearly $30 million grant from the National Institutes of Health (NIH) to continue its mission of accelerating research discoveries across Indiana and beyond.

  Dr. Jenifer Prosperi, a researcher at the Harper Cancer Research Institute, is studying how to treat breast cancers that evolve when a crucial tumor suppressor gene goes silent. Over the past 15 years, the scientific community has come to understand…

New research published in the journal Nature Chemical Biology shows that a group of scientists, led by faculty at the University of Notre Dame, has made concrete progress toward the development of the first-ever inhibitory therapeutic for type-I hypersensitive allergic reactions.

  University of Notre Dame researchers Shahriar Mobashery and Mayland Chang and their collaborators in Spain have published research results this week that show how methicillin-resistant Staphylococcus aureus (MRSA) regulates the critical crosslinking of its cell wall in the face of beta-lactam antibiotics. The work, published in the Proceedings of...

At the Harper Cancer Research Institute, Dr. Karen Cowden Dahl is leading research on ARID3B, a mysterious gene that could hold promise for identifying more aggressive forms of ovarian cancer. Standing at a microscope in her Harper Hall laboratory, Dr. Karen Cowden Dahl is scanning…

A new paper by Zoltán Toroczkai, professor of physics and concurrent professor of computer science and engineering at the University of Notre Dame, and his collaborators provides a predictive model of cerebral cortical connectivity at the interareal level. The study was published in the Oct. 2 issue of the journal...

Imagine your children, your nieces, nephews, or grandchildren losing a parent to cancer. Too many experiences and dreams are ripped away due to this terrible disease. But with new, more effective cancer treatments being developed, the prognosis for cancer patients is improving little by little. …

Imagine your children, your nieces, nephews, or grandchildren losing a parent to cancer. Too many experiences and dreams are ripped away due to this terrible disease. But with new, more effective cancer treatments being developed, the prognosis for cancer patients is improving little by little. …

A new study by a team of University of Notre Dame researchers, which appears in the Sept. 2 edition of the journal PLoS ONE, is a significant step in understanding the molecular genetic and physiological basis for a spectrum of metabolic diseases related to circadian function. Obesity and diabetes have...

Patricia L. Clark, the Rev. John Cardinal O’Hara, C.S.C. Professor of Chemistry and Biochemistry, has received a $3.8M award from the National Institutes of Health (NIH) to lead a pioneering model of collaboration that draws together seven institutions, eight co-PIs and six postdoctoral associates to study macromolecular interactions in living...

The University of Notre Dame has established a formal partnership with Bruker Corp., a world leader in scientific instrumentation. The partnership will develop one of the Midwest’s top imaging facilities at Notre Dame. The arrangement, called Bruker at Notre Dame (BAND), will allow the Notre Dame Integrated Imaging Facility (NDIIF)...

A pair of studies by a team of University of Notre Dame researchers led by Crislyn D’Souza-Schorey, professor of biological sciences, sheds light on a biological process that is activated across a vast range of malignancies. Wnt proteins are a large family of proteins that activate signaling pathways (a set...

Walther ENSCCII Training Project 2013 Awardees The overall goal of the Walther ENSCCII Training Project is to establish a cancer-focused integrative inter-disciplinary training environment.  Three years of pre-doctoral or post-doctoral support are provided to highly qualified and productive applicants.

Research being carried out at the University of Notre Dame and its affiliated Harper Cancer Research Institute (HCRI) may lead to the development of a rapid, cost-effective means of screening for oral cancers and the human papillomavirus. M. Sharon Stack, Ann F. Dunne and Elizabeth Riley Director of the HCRI...

  A new study by a team of researchers from the University of Notre Dame provides an important new insight into how cancer cells are able to avoid the cell death process. The findings may reveal a novel chemotherapeutic approach to prevent the spread of cancers. Metastasis, the spread of...

The University of Notre Dame will host the XIV International Workshop on Molecular and Cellular Biology of Plasminogen Activation from June 4 through June 8 (Tuesday through Saturday). The co-chairs of the conference are Francis J. Castellino and Victoria A. Ploplis of Notre Dame’s W. M. Keck Center for Transgene...

Dr. Anil K. Sood, Professor of Gynecologic Oncology and Cancer Biology at the MD Anderson Cancer Center, was the Keynote Speaker to a capacity crowd in Raclin-Carmichael Hall at the Second Annual HCRI Research Day on April 15. 

Brian Baker, associate professor of chemistry and biochemistry, has been selected as an associate editor for Journal of Immunology.  The journal publishes peer-reviewed articles in all areas of experimental immunology, which includes both basic and clinical studies. All editors of the bi-monthly journal are practicing scientists and the publication is...

Watch Video University of Notre Dame researchers have successfully created three-dimensional anatomical models from CT scans using 3-D printing technology, a process that holds promise for medical professionals and their patients. A paper by the researchers, “3D Printing of Preclinical X-ray Computed Tomographic Data Sets,” was published in the Journal...

A potential landmark paper by Notre Dame researchers could help identify and adjust important parameters for designing targeted nanoparticle-based cancer treatments for years to come. At the same time, the results of the study shed light on a decades-long debate among cancer researchers.

Mary Hesburgh Flaherty, a 1979 Notre Dame alumna and two-time breast cancer survivor, spoke about her experience with cancer at the third annual Pink Zone Luncheon on Feb. 2. Each year the luncheon is hosted by the College of Science and the Notre Dame women’s basketball team to honor breast cancer researchers, clinicians, and...

M. Sharon Stack, Ann F. Dunne and Elizabeth Riley Science Director of the Harper Cancer Research Institute and professor of chemistry and biochemistry, was recently named to the board of the journal Cancer Research. Her term will last from January 1, 2013 to December 21, 2015. Cancer Research is a bi- monthly journal that publishes...