"Monitoring the Movement of Molecules in the Body via Real-time Aptamer-based Sensors" Abstract:   Electrochemical, aptamer-based sensors (E-ABs) enable specific, continuous, and real-time molecular measurements in vivo. Their selectivity and modularity stem from the use of nucleic acid aptamers—single-stranded DNA oligos selected in vitro for their ability to bind specific molecular targets. To create E-ABs, redox-reporter-modified aptamers are attached to gold electrodes via thiol-based self-assembly. These modified aptamers are engineered to exhibit two thermodynamic states: an unbound, slow electron-transferring state in the absence of the target, and a bound, fast electron-transferring state in the presence of the target. The two...

Justin Webster University of Maryland, Baltimore County 154 Hurley Hall3:30 pm - 4:30 pm Stability and Periodicity in PDE Systems Time-periodic behavior can arise in multi-physics systems as (i) a response to periodic forcing (blood flow in human tissues) or (ii)…

Hui Zhang Northwestern Medicine, Feinberg School of Medicine 3:45 PM127 Hayes-Healy CenterA tea will precede the event at 3:15 pm…

     CBBI "Targeting Histone Deacetylases for Cancer Therapy and Beyond"

     Warren Center Lecure Like a Champion Series "Elucidating Small Molecule-DNA Binding Mechanisms with Molecular Dynamics Simulations" Steven Corcelli "Computational Studies of Ebola VP40, the Swiss Army Knife of Proteins" Olaf Wiest

Former William K. Warren Foundation Dean of the Notre Dame College of Science, Gregory P. Crawford, who is now the 22nd president of Miami University; Sean Kassen, director of the Ara Parseghian Medical Research Fund; Barbara Calhoun, assistant professor of the practice and the Reisenauer Family Director…

Bayesian Weighted Learning in Dynamic Treatment Regime

Please join the Department of Biological Sciences for a seminar featuring Dr. Christopher Patzke, John M. and Mary Jo Boler Assistant Professor. Originally published at biology.nd.edu.

Dissertation title: "Elucidating the Genetic Determinants of Drug Response in Plasmodium falciparum" Advisor: Michael Ferdig Contact Cheryl Schairer for Zoom link, cschaire@nd.edu

     CBBI "Exploring Peptidoglycan Glycosidases as Targets for Developing Novel Antimicrobial Therapeutic Strategies"

Title: "Defining the fungal-host interactions between the pathogenic yeast Cryptococcus neoformans and human microglia"