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News » Archives » July 2013

Notre Dame-Bruker partnership promotes advancements in imaging

Author: Marissa Gebhard

Example PET, SPECT and CT images from the Albira at the Notre Dame In Vivo Imaging Facility

The University of Notre Dame has established a formal partnership with Bruker Corp., a world leader in scientific instrumentation. The partnership will develop one of the Midwest’s top imaging facilities at Notre Dame. The arrangement, called Bruker at Notre Dame (BAND), will allow the Notre Dame Integrated Imaging Facility (NDIIF) and Bruker to collaborate on research, training and new application development.

Robert J. Bernhard, Notre Dame’s vice president for research, said the agreement will accelerate a wide range of research, education and outreach activities. “The partnership will enable Notre Dame students and faculty to utilize innovative technology from Bruker in our programs, which we believe will also inform Bruker about future markets,” he said. “We believe this partnership will be mutually beneficial to both parties and are very pleased to formalize our relationship.” Read More

Notre Dame researchers offer new insights on cancer cell signaling

Author: William G. Gilroy

Wnt proteins and cancer cell signaling

A pair of studies by a team of University of Notre Dame researchers led by Crislyn D’Souza-Schorey, professor of biological sciences, sheds light on a biological process that is activated across a vast range of malignancies.

Wnt proteins are a large family of proteins that activate signaling pathways (a set of biological reactions in a cell) to control several vital steps in embryonic development. In adults, Wnt-mediated functions are frequently altered in many types of cancers and, specifically, within cell subpopulations that possess stem cell-like properties. Read More

New paper offers insights into how cancer cells avoid cell death

Author: William G. Gilroy

 

A new study by a team of researchers from the University of Notre Dame provides an important new insight into how cancer cells are able to avoid the cell death process. The findings may reveal a novel chemotherapeutic approach to prevent the spread of cancers.

Metastasis, the spread of cancer from one organ to other parts of the body, relies on cancer cells’ ability to evade a cell death process called anoikis, according to Zachary T. Schafer, Coleman Assistant Professor of Cancer Biology at Notre Dame. Metastasizing cancer cells are able to block anoikis, which normally results from detachment from the extracellular matrix. However, Schafer notes that the molecular mechanisms that cancer cells detached from the extracellular matrix use to survive have not been well understood. Read More

Notre Dame and Harper researchers developing novel method to test for HPV and oral cancers

Author: William G. Gilroy

Research being carried out at the University of Notre Dame and its affiliated Harper Cancer Research Institute (HCRI) may lead to the development of a rapid, cost-effective means of screening for oral cancers and the human papillomavirus.

M. Sharon Stack, Ann F. Dunne and Elizabeth Riley Director of the HCRI and professor of chemistry and biochemistry, points out that oral cancers are a significant global health problem.

Stack and Hsueh-Chia Chang, Bayer Professor of Engineering and director of Notre Dame’s Center for Microfluidics and Medical Diagnostics, are attempting to prescreen for oral cancer and HPV by examining the micro-RNAs of tumor cells. They are working on developing a microfluidic sensor to help detect the presence of tumor cells. Read More