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Water discovered to form column of hydration at surface of DNA

Author: Deanna Csomo McCool

Steven Corcelli named ACS Fellow

Scientists have been aware since Watson and Crick first reported the double helix structure of DNA in 1953 that water had an important relationship with the biomolecule. But finally observing the spectroscopic signature of the column of water is a breakthrough with implications for cancer drugs and other biomedical research. Read More

Developing the Gold Standard for Efficient Diagnostics

Author: Brandi Klingerman

Notre Dame researchers are improving the speed and practicality of detecting disease

To detect an illness in the body, common diagnostic tests like the enzyme-linked immunosorbent assay (ELISA) are used. Unfortunately, ELISA takes hours to process and requires expert analysis, limiting its benefits for developing countries and those who require immediate results. In order to combat these challenges, Notre Dame researchers have been working to develop an improved test and have recently published a study on a new diagnostic method that uses gold nanoparticles, requires little to no expertise, and provides results in minutes.

Nur 2Nur Mustafaoglu, a Chemical and Biomolecular Engineering graduate student and Advanced Diagnostics and Therapeutics (AD&T) Berry Family Graduate Fellow Read More

Results of new research on organ transplants can lead to new cancer treatments

Author: Deanna Csomo McCool

Biochemist Brian Baker was struck with an idea for potentially treating cancer when he considered the relationship between a type of treatment being tried on babies with blood cancers, and a molecule that attacked the hepatitis C virus in a liver transplant patient.

Brian Baker 250

Baker, a researcher with the Mike and Josie Harper Cancer Research Institute and the John A. Zahm Professor of Structural Biology, along with graduate students Yuan Wang and Nishant Singh, launched into research with immunologists from Loyola University in Chicago to discover how molecules within T-cells (the subtype of a white blood cell responsible for sensing whether you’re healthy or have an infection) can specifically target certain cells to kill them. Read More

The Power of Computational Modeling to Combat Diseases

Author: Sarah Craig

For people living in the US, the Zika epidemic of 2016 seemed to have come out of nowhere and to have now almost disappeared. Zika infections and microcephaly in newborns were daily headline news. Now where are we? 

Alex Perkins, PhD, Eck Family Assistant Professor in the Department of Biological Sciences, and a member of the Eck Institute for Global Health, is among the nation’s leading researchers in a unique and growing area within this complex field of disease control and prevention. The Perkins Lab at the University of Notre Dame applies mathematical modeling to the study of infectious disease transmission dynamics and control with a focus on mosquito-borne diseases including, but not limited to, Zika, dengue, and malaria.

Alexperkins 1200 Read More

Immunotherapy team shares grand prize in McCloskey Business Plan Competition

Author: Deanna Csomo McCool

Structured Immunity 250

The interdisciplinary team of Structured Immunity patented a new technology for the field of immunology that can increase drug efficacy to kill cancer cells, while decreasing the possibility of side effects. The start-up shared the grand prize in the McCloskey Business Plan competition in April. Read More

Xin Lu Wins CTSI Young Investigator Award

Author: M. Sharon Stack, PhD

Xin Lu

Professor Xin Lu, the John M. and Mary Jo Boler Assistant Professor of Biological Sciences, has been awarded a Young Investigator Award from the Indiana Clinical and Translational Sciences Institute (CTSI). This award provides salary support and seed funding for the period of one year, as well as access to additional pilot funding opportunities.

Lu received the award to support his work on targeting of metastatic prostate cancer using novel antibody-drug conjugates (ADCs). These innovative biopharmaceuticals combine a potent “payload," consisting of a toxic drug, with a highly selective antibody that targets the payload to tumor cells Read More

Notre Dame Researcher receives Grant to study Spinal Cord Injuries

Author: Brandi Klingerman

Cody Smith 9859Professor Cody J. Smith

The Indiana State Department of Health and the Indiana Clinical and Translational Sciences Institute (CTSI) has awarded Cody J. Smith, the Elizabeth and Michael Gallagher Assistant Professor of Biological Sciences and affiliated member of the Center for Stem Cells and Regenerative Medicine, a Spinal Cord and Brain Injury Research Fund (SCBIRF) grant. The aim of Smith’s work will be to understand the limiting factors of sensory nerve regeneration in spinal cord injuries with the goal of improving regeneration capacity in certain nerves. Read More

Notre Dame Imaging Facility to host 4th Annual Microscopy Workshop

Author: Brandi Klingerman

Brad Smith, ImagingDirector Bradley Smith

On Tuesday, May 9th and Wednesday, May 10th, the Notre Dame Integrated Imaging Facility (NDIIF) will host its annual Midwest Imaging and Microanalysis Workshop. The event will feature presentations from faculty across the region, including Purdue University and the University of Michigan, and focus on highlighting new trends of in-situ and high-resolution electron microscopy for nanotechnology, materials, and biosciences. Read More

Apply Today for these open Indiana CTSI Grants

Author: Bruce Melancon

There are currently four open Indiana Clinical and Translational Sciences Institute grant opportunities.

The Indiana CTSI is seeking applicants for the Collaboration in Translational Research (CTR) Pilot Grant Program. The objective of the Indiana CTSI CTR pilot grant program is to foster and encourage collaboration across the Indiana CTSI partner institutions (IU, Purdue, and Notre Dame) and to initiate or continue translational research projects that have very strong and immediate potential to develop into larger, externally funded research programs, or generate novel intellectual property (IP). Read More