Abstract:  A biosensor capable of continuously measuring specific molecules in the bloodstream in vivowould give clinicians a valuable window into patients’ health and their response to therapeutics. Unfortunately, continuous, real-time measurement is currently only possible for a handful of targets (i.e.glucose, and oxygen) and existing platforms for continuous measurement are not generalizable for the monitoring of other analytes.  In this talk, we will present a universal real-time biosensor technology capable of continuously tracking a wide range of circulating molecules in living animals.  Our real-time biosensor requires no exogenous reagents and can be readily reconfigured to measure different target molecules by exchanging molecular probes in a modular manner. Next, we will present the first real-time, closed loop feedback control of drug concentration in live animals using the real-time biosensor, and discuss potential applications of our technology.  Finally, we will discuss methods for generating synthetic molecular probes (aptamers) that are at the heart of these biosensor technologies

Originally published at chemistry.nd.edu.