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Faculty Seminar with Professor Siyuan Zhang

Author: Khoa Huynh

Zhang Seminar

Join Siuyan Zhang, the Nancy Dee Assistant Professor of Cancer Research and Assistant Professor of Biological Sciences at the University of Notre Dame, on Tuesday, October 10, 2017 at 4:00pm in 283 Galvin for a seminar titled Unraveling Bewildered Tumor Ecosystem – From Molecular Insights to Clinical Translation. Read More

Harper Cancer Research Institute Community Seminar to focus on Breast Cancer Sept. 13

Author: Erin Blasko

Harper Cancer Feature

The Mike and Josie Harper Cancer Research Institute at the University of Notre Dame will host a community breast cancer seminar Sept. 13 (Wednesday) at Raclin-Carmichael Hall, 1234 N. Notre Dame Ave., as part of its occasional Community Seminar Series.

Doors open at 5 p.m., followed by presentations and a Q&A from 5:30 to 6:30 p.m. with Judy Nace, a local breast cancer survivor, and Jeni Prosperi, assistant professor of biochemistry and molecular biology at Indiana University School of Medicine-South Bend and adjunct assistant professor of biological sciences at Notre Dame. Read More

New Notre Dame ideas with potential to improve health and wellness secure funding

Author: Arnie Phifer

Research extends from the most common cause of heart attacks to a rare brain disorder affecting children

 

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The University of Notre Dame’s Advanced Diagnostics & Therapeutics (AD&T) initiative announced the recipients of its 2017 Discovery Fund awards, which provide seed funding to some of the most creative ideas being developed by Notre Dame faculty and their collaborators in areas of biomedical, environmental, and behavioral health.

 

Since 2013, AD&T has used its Discovery Fund program to support new projects identified by their scientific originality, multidisciplinary approaches, and likelihood to result in real-world applications and products.

 

“Our Discovery Fund awards have proven to be great investments,” says Paul Bohn, Schmitt Professor of Chemical and Biomolecular Engineering, Professor of Chemistry and Biochemistry, and Director of AD&T.

 

“Not only do we back faculty and students doing exciting, potentially transformative work, but so far every dollar we’ve invested has returned an additional $15 in external grant support. Many have also resulted in commercializable intellectual property. Those are the kinds of outcomes that produce long-term research sustainability.” Read More

Join Notre Dame Research for the 2017 Core Facility Fair

Author: Brandi Klingerman

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Notre Dame Research invites faculty, staff, post-doctoral scholars, graduate and undergraduate students, as well as external customers to attend the Core Facility Fair on Wednesday, September 20, 2017. From 12:00 to 4:00 p.m. in the McCourtney Hall B01 Auditorium, attendees will be able to learn how state-of-the-art instrumentation and expertise available via the University of Notre Dame core facilities can help take their research to the next level.  Read More

Researchers tackle ovarian cancer using a multidisciplinary approach

Author: Deanna Csomo McCool

Sharon Stack, Ann F. Dunne and Elizabeth Riley Science Director of the Harper Cancer Research Institute and professor of chemistry and biochemistry

Researchers at the Harper Cancer Research Institute, which is a collaboration between the University of Notre Dame and the Indiana University School of Medicine South Bend (IUSM-SB), are working with community partners to not only foster awareness of ovarian cancer, but to develop tests for early detection, create novel chemotherapies, and target the Holy Grail: A cure. Read More

New End Point Strategy for Disease Elimination

Author: Sarah Craig

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The University of Notre Dame’s Edwin Michael, Professor, Department of Biological Sciences and member of the Eck Institute for Global Health, and his team of researchers have developed a model to assess the utility of using dyethalcarbamazine (DEC) treated salt. Their research was recently published in Nature’s Scientific Reports, a peer-reviewed journal publishing topic areas and methods that address essential public health questions relating to infectious diseases of poverty. Read More

Dr. Jeremy Zartman Awarded Highly Competitive NIH Grant

Author: Khoa Huynh

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Dr. Jeremy Zartman, Assistant Professor of Chemical and Biomolecular Engineering, has been awarded a competitive Maximizing Investigators’ Research Award (MIRA, R35) grant from the National Institutes of Health.  The MIRA program is intended to provide research support for "the nation’s highly talented and promising investigators”.  Zartman’s 5-year grant entitled Regulation and Function of Multicellular Calcium Signaling in Epithelial Growth and Regeneration will support an investigation of impaired cellular calcium signaling, prevalent in many diseases including skin diseases, Alzheimer’s, and metastatic cancer. Read More

College of Science & Engineering Joint Annual Meeting

Author: Khoa Huynh

2017 Cose Jam Grad Students Postdocs Flier

The College of Science (COS) and College of Engineering (COE) will be hosting the first-ever Joint Annual Meeting on Friday, December 8, 2017 in Jordan Hall of Science. This event will provide an interdisciplinary forum to showcase the diverse research strengths of the graduate students and postdoctoral trainees in both the COS and COE

Contact:

Matthew J. Ravosa / Professor of Biological Sciences, Aerospace and Mechanical Engineering, and Anthropology

mravosa@nd.edu 

Originally published by Khoa Huynh at harpercancer.nd.edu on August 29, 2017. Read More

The Rise of Nanotechnology Research at Notre Dame

Author: Brandi Klingerman

Researchers at NDnano  look two steps ahead to stand apart in a competitive field

Vt1k8651Professor Porod in the lab with a graduate student

Notre Dame’s nanotechnology research efforts date back to the 1980s, when the studies were mostly simulation-based and focused on computation advancements. In the three decades since, research at the University’s Center for Nano Science and Technology (NDnano) has grown and evolved in a forward-thinking and distinctive way. Read More

Researchers work to Unlock Clues to How Cells Move through the Body

Author: Nina Welding

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A team of researchers, led by Notre Dame's Zhangli Peng and co-investigator Juan del Alamo of the University of California at San Diego, is studying the transmigration of red blood cells through inter-endothelial slits in the spleen, the narrowest point in the body through which these cells travel, to provide important clues in a variety of physiological and pathological processes and potentially impact the design of artificial organs and other biomedical devices. Read More

Slashing sweets before chemo may make treatment more effective

Author: Deanna Csomo McCool

Colorectal cancer patients may benefit by avoiding sweets for three days before chemotherapy and by taking a common antimalaria drug, according to new research by biochemistry doctoral student Monica Schroll.

Monica Schroll HorizontalMonica Schroll

Schroll, Amanda Hummon, associate professor of chemistry and biochemistry, and two others studied a two-pronged method of weakening colorectal cancer cells to improve the effectiveness of chemotherapy, Read More

New research suggests climate change could accelerate mosquito-borne disease epidemics

Author: Sarah Craig

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Bad news for humans about the spread of mosquito-borne disease as climate change continues to worsen. New research from the University of Notre Dame, recently published in PLOS Neglected Tropical Diseases, proposes a new way that climate change could contribute to mosquitos’ capacity to drive disease epidemics. As climate change continues to rise, so could the speed of epidemics of mosquito-borne diseases like dengue and Zika.    Read More

Radiation Laboratory researchers unveil neutral radicals in new process

Author: Deanna Csomo McCool

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Researchers at the Notre Dame Radiation Laboratory have devised a process to detect neutral radicals, which if more thoroughly understood can be used to improve radiotherapy to kill cancer cells or advance the manufacture of semiconductor chips, among other applications. Read More

Webber Named to Class of 2017 Emerging Investigators

Author: Nina Welding

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Biomaterials Science has named Matthew Webber, assistant professor of chemical and biomolecular engineering and director of the Supramolecular Engineering Laboratory at the University of Notre Dame, to its 2017 Class of Emerging Investigators. Chosen for their outstanding work in the field of biomaterials, each of the 31 young researchers is highlighted in the July issue of the journal, which includes articles ranging from findings in nanomedicine to biomimetic materials to molecular delivery systems for applications including cancer therapy, imaging and tissue engineering.
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2017 Walther Cancer Foundation Grants Winners

Author: Khoa Huynh

Walther Grants Logo

We are pleased to announce the awardees of the 2017 Walther Cancer Foundation Cancer Cure Venture (CCV) and Interdisciplinary Interface Training Program (IITP) grants. The overall goals of the CCV funding mechanism is to stimulate novel multi-disciplinary integrative cancer research, seed collaborative interactions between at least 2 scientific fields, provide cross-disciplinary training environment for post-doctoral fellows, and generate high quality preliminary data for extramural application. The IITP funding mechanism aims to establish cancer-focused integrative interdisciplinary training environment, provide 2 years of support for highly qualified and productive applicants, and demonstrate efficacy of this training model to support future NIH T32 application.  

CCV AWARDEES:

Collaborators: Siyuan Zhang, Nancy Dee Assistant Professor of Cancer Research, Assistant Professor of Biological Sciences; Pinar Zorlutuna, Assistant Professor of Aerospace and Mechanical Engineering

Project Title: An Aging-mimicking Breast-on-Chip (ABoc) for Studying the Effect of Aged Microenvironment on Breast Cancer Progression

Collaborators: Xin Lu, John M. and Mary Jo Boler Assistant Professor Department of Biological Sciences; Matt Webber, Assistant Professor of Chemical and Biomolecular Engineering

Project Title: Novel Antibody-Drug Conjugates for Personalized Therapy of Lethal Prostate Cancer

IITP AWARDEES

Student: Marwa Asem

Mentors: Sharon Stack, Ann F. Dunne and Elizabeth Riley Director of Harper Cancer Research Institute, Kleiderer-Pezold Professor of Chemistry & Biochemistry; Matt Ravosa, Professor of Biological Sciences, Aerospace and Mechanical Engineering, and Anthropology; Pinar Zorlutuna, Assistant Professor of Aerospace and Mechanical Engineering

Project Title: Intra-peritoneal Mechanobiology and Tumor:Host Crosstalk in Ovarian Cancer

Student: Austin Boucher Read More

Notre Dame research funding reaches record-breaking levels

Author: Joanne Fahey and Brandi Klingerman

Notre Dame Research

The University of Notre Dame has received $138.1 million in research funding for fiscal year (FY) 2017, surpassing the previous record of $133.7 million set in FY 2015. Additionally, the University also broke its monthly record receiving $27.6 million in June alone. Read More

Notre Dame Research Launches New Module on ND Mobile

Author: Brandi Klingerman

The module features the University’s key research areas, core facilities, and research news

Notre Dame Research (NDR) has launched a new module on the ND Mobile App. This module provides a snapshot of the research taking place at the University of Notre Dame while also providing important information for those conducting research on campus.

When discussing the module, Research Communications Program Director Joanne D. Fahey said, “ND Mobile allows its users to learn about everything from athletics to campus dining, and now the app will also offer that same level of accessibility and awareness for Notre Dame Research. Whether someone is visiting campus or is a faculty member or student, the ND Mobile App now provides an additional, easy-to-use resource to learn more about research, scholarship, and creative endeavor here at Notre Dame.”

The module offers five main sections: Our Research, How Do I…?, Twitter, News, and Contact. The ‘Our Research’ section offers insight into research in the colleges and schools as well as the University’s key research areas and core facilities. Like research.nd.edu, ND Mobile users can now view videos or photos, read short descriptions, and find resource links for various research centers and institutes on campus. Read More

Eck Institute for Global Health to study Zika in Belize

Author: Jessica Sieff

Eck Institute for Global Health to study Zika in Belize

The University of Notre Dame has announced a collaboration with Mayo Clinic, the Belize Ministry of Health and the Belize Vector and Ecology Center aimed at strengthening the country’s ability to respond to Zika virus and other arboviruses. Researchers are already working in Belize as part of the five-year project, which will include a full epidemiological and entomological surveillance study, training for health care professionals and public health awareness and education. Read More

New Studies Show Molecular Make-up of Ovarian Cancer May Determine Speed of New Tumor Growth

Author: Brandi Klingerman

Key to understanding ovarian cancer metastasis could lie in cancer cells acting in groups

Cells in the Stack LabOvarian cancer cell tearing apart the mesothelial layer of the peritoneum.

When it comes to ovarian cancer, 60 percent of patients are diagnosed in stage III, meaning the cancer has already metastasized, or spread, throughout the pelvis. Additionally, between 70 and 90 percent of those patients will be diagnosed with recurrence and although recurrent ovarian cancer is treatable, it is rarely curable. These unfortunate results are partially due to the disease’s ability to spread cancer cells and therefore efficiently penetrate other organs. To better understand how metastatic ovarian cancer spreads, Notre Dame researchers at the Harper Cancer Research Institute (HCRI) are evaluating the impact of ovarian cancer cell molecular composition and how these cells work together to invade surrounding tissue. Read More

Notre Dame graduate students awarded fellowships for cross-disciplinary biomedical research

Author: Arnie Phifer

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Two University of Notre Dame graduate students, Enrico Speri and Yide Zhang, have been awarded the 2017 Berry Family Foundation Graduate Fellowships in Advanced Diagnostics & Therapeutics to support their exceptional  and wide-ranging research programs—which touch on aspects of biology, chemistry, and engineering—over the next academic year.

 

Speri, a chemistry and biochemistry PhD student working in the labs of Shahriar Mobashery and Mayland Chang, is trying to tackle one of the largest global health threats today: bacterial resistance to antibiotics. Read More

Water discovered to form column of hydration at surface of DNA

Author: Deanna Csomo McCool

Steven Corcelli named ACS Fellow

Scientists have been aware since Watson and Crick first reported the double helix structure of DNA in 1953 that water had an important relationship with the biomolecule. But finally observing the spectroscopic signature of the column of water is a breakthrough with implications for cancer drugs and other biomedical research. Read More

Developing the Gold Standard for Efficient Diagnostics

Author: Brandi Klingerman

Notre Dame researchers are improving the speed and practicality of detecting disease

To detect an illness in the body, common diagnostic tests like the enzyme-linked immunosorbent assay (ELISA) are used. Unfortunately, ELISA takes hours to process and requires expert analysis, limiting its benefits for developing countries and those who require immediate results. In order to combat these challenges, Notre Dame researchers have been working to develop an improved test and have recently published a study on a new diagnostic method that uses gold nanoparticles, requires little to no expertise, and provides results in minutes.

Nur 2Nur Mustafaoglu, a Chemical and Biomolecular Engineering graduate student and Advanced Diagnostics and Therapeutics (AD&T) Berry Family Graduate Fellow Read More

Results of new research on organ transplants can lead to new cancer treatments

Author: Deanna Csomo McCool

Biochemist Brian Baker was struck with an idea for potentially treating cancer when he considered the relationship between a type of treatment being tried on babies with blood cancers, and a molecule that attacked the hepatitis C virus in a liver transplant patient.

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Baker, a researcher with the Mike and Josie Harper Cancer Research Institute and the John A. Zahm Professor of Structural Biology, along with graduate students Yuan Wang and Nishant Singh, launched into research with immunologists from Loyola University in Chicago to discover how molecules within T-cells (the subtype of a white blood cell responsible for sensing whether you’re healthy or have an infection) can specifically target certain cells to kill them. Read More

The Power of Computational Modeling to Combat Diseases

Author: Sarah Craig

For people living in the US, the Zika epidemic of 2016 seemed to have come out of nowhere and to have now almost disappeared. Zika infections and microcephaly in newborns were daily headline news. Now where are we? 

Alex Perkins, PhD, Eck Family Assistant Professor in the Department of Biological Sciences, and a member of the Eck Institute for Global Health, is among the nation’s leading researchers in a unique and growing area within this complex field of disease control and prevention. The Perkins Lab at the University of Notre Dame applies mathematical modeling to the study of infectious disease transmission dynamics and control with a focus on mosquito-borne diseases including, but not limited to, Zika, dengue, and malaria.

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Immunotherapy team shares grand prize in McCloskey Business Plan Competition

Author: Deanna Csomo McCool

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The interdisciplinary team of Structured Immunity patented a new technology for the field of immunology that can increase drug efficacy to kill cancer cells, while decreasing the possibility of side effects. The start-up shared the grand prize in the McCloskey Business Plan competition in April. Read More