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Breakthrough in Niemann-Pick Type C research reported by Notre Dame and Cornell scientists

Author: William G. Gilroy

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A paper announcing a breakthrough discovery in the fight against Niemann-Pick Type C, coauthored by Olaf Wiest and Paul Helquist of the University of Notre Dame’s Department Chemistry and Biochemistry and Frederick Maxfield, Chair of Biochemistry at Cornell University Weill College of Medicine, appears in the Proceedings of the National Academy of Science this week. The paper shows how use of a histone deacetylase inhibitor corrects the damage done by the genetic disorder and allowed once-diseased cells to function normally. Read More

Malcolm Fraser elected fellow of American Academy of Microbiology

Author: William G. Gilroy

Malcolm Fraser

Malcolm J. Fraser Jr., professor of biological sciences at the University of Notre Dame, has been elected a fellow of the American Academy of Microbiology, an honorary leadership group within the American Society for Microbiology. The election recognizes Fraser’s long record of teaching and innovative research, especially in the fields of virology and transgenic engineering.

Fraser discovered the piggyBac transposon, characterized its function and developed it as a “universal” transgenesis system. The system has been applied in many medically and economically important species that previously lacked efficient transformation systems, including the malaria-causing protozoan parasite, disease-carrying mosquitoes, silk moths, and grain beetles. Read More