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Genomics & Proteomics

Genomics & Proteomics

Researchers in the IBMS Genomics and Proteomics cluster study the information content of cells:  their genomes and the sets of proteins they code for. Ongoing genomic studies range from investigations of genome structure and architecture to comparative genomics of pathogens and model organisms. In proteomics, ongoing studies include comparative analyses of the proteomes of normal and diseased tissues, studies of proteomic changes as a function of cellular differentiation and tissue microenvironment, and development of next-generation proteomic methods. Significant resources exist for high throughput, high volume DNA and protein sequencing and detailed analyses of complex, information-rich biochemical and biological samples. Students in the cluster learn how to identify and quantify changes in gene expression, from the single microRNA level up to global alterations in a proteome.

Image: Imaging of protein expression in tumor cell spheroids via MALDI mass spectrometry. Courtesy of the laboratory of Amanda Hummon

Contact

Genomics & Proteomics

Matthew Champion (website>)
Department of Chemistry & Biochemistry
Contact by email
574-631-1787

 

 

 

 

Participating Faculty

Steven Buechler

Applied & Computational Mathematics & Statistics

Application of statistics to genetics and personalized medicine

Francis J. Castellino

Chemistry and Biochemistry

In vitro and in vivo relationships between hemostasis and inflammation

Matthew Champion

Chemistry and Biochemistry

Primarily interested in developing and exploiting novel approaches to identify and characterize the components of secreted proteins from virulent microorganisms.

Frank Collins

Biological Sciences

Genome level studies of arthropod vectors of human pathogens; field and laboratory research on malaria vectors

Norman Dovichi

Chemistry and Biochemistry

Proteomics

Crislyn D'Souza-Schorey

Biological Sciences

Signal integration and cancer progression
 

John Duman

Biological Sciences

Physiological adaptations to subzero temperature; antifreeze proteins

Scott Emrich

Department of Computer Science and Engineering; Biological Sciences

Genome-focused bioinformatics and applications to global health and ecology; high throughput computing, cyberinfrastructure, genome analysis (VectorBase, i5K)

Michael Ferdig

Biological Sciences

Genetics and genomics of drug resistance and virulence in the malaria parasite

Kasturi Haldar

Biological Sciences

Understanding disease pathology and developing treatments in rare and neglected diseases

Paul W. Huber

Chemistry and Biochemistry

RNA expression, processing, and localization

Amanda Hummon

Chemistry and Biochemistry

Proteomics of cancer cells
 

David R. Hyde

Biological Sciences

Visual System Development and Dysfunction
 

Laurie Littlepage

Chemistry and Biochemistry

Modeling cancer progression in vivo to develop biomarkers and therapies; contributions of the microenvironment to breast and prostate cancers

Xin Lu

Biological Sciences

Molecular Understanding and Immunotherapy of Metastatic Cancer; Novel Animal Models for Rare Cancers

Mary Ann McDowell

Biological Sciences

Immunoparasitology

Athanasia Panopoulos

Biological Sciences

Somatic cell reprogramming; cancer therapeutics and regenerative medicine

Michael Pfrender

Biological Sciences

Ecological genomics; adaptation in natural populations; plasticity

Molly Duman Scheel

Medical and Molecular Genetics (IUSM-SB) and Biological Sciences (ND)

Genetic and comparative analysis of invasive cellular growth; vector mosquito developmental genetics

David Severson

Biological Sciences

Mosquito Genetics and Genomics
 

Cody J. Smith

Biological Sciences

Development and Regeneration of the Nervous System

Gregory Timp

Biological Sciences

Single molecule spectroscopy; next generation sequencing; synthetic biology

Kevin Vaughan

Biological Sciences

Molecular basis of organelle transport