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Computational Biology & Bioinformatics

Computational Biology & Bioinformatics

Researchers in the IBMS Computational Biology and Bioinformatics cluster model the behavior of biological molecules and biomolecular systems across a range of time and length scales. Studies range from atomic simulations of proteins and carbohydrates to the generation of computational models for processes such as protein folding and interactions, the growth and regulation of the cytoskeleton, and multicomponent and multicellular emergent behavior. Additional studies extract detail from large biochemical datasets, using computational algorithms to identify patterns in gene expression, genome sequences, and metabolic networks. Although their research questions are diverse, students in the cluster share a common goal of addressing key biomedical problems using sophisticated computational algorithms.

Image: Microarray data tracking the expression of multiple genes in real time.


Computational Biology & Bioinformatics

Michael Ferdig (website>)
Department of Biological Sciences
Contact by email
(574) 631-9973

Participating Faculty

Brian M. Baker

Chemistry and Biochemistry

Structural biology and biophysics of recognition and signaling in immunity, cancer, and antibiotic resistance

Steven Buechler

Applied & Computational Mathematics & Statistics

Application of statistics to genetics and personalized medicine

Patricia L. Clark

Chemistry and Biochemistry

Protein biophysics in living cells

Frank Collins

Biological Sciences

Genome level studies of arthropod vectors of human pathogens; field and laboratory research on malaria vectors

Steve Corcelli

Chemistry and Biochemistry

Theoretical and computational studies of reaction dynamics

Scott Emrich

Department of Computer Science and Engineering; Biological Sciences

Genome-focused bioinformatics and applications to global health and ecology; high throughput computing, cyberinfrastructure, genome analysis (VectorBase, i5K)

Michael Ferdig

Biological Sciences

Genetics and genomics of drug resistance and virulence in the malaria parasite

Holly Goodson

Chemistry and Biochemistry; Biological Sciences

Molecular and cell biology and biophysics

Kasturi Haldar

Biological Sciences

Understanding disease pathology and developing treatments in rare and neglected diseases

Reginald Hill

Biological Sciences

Inflammation and chemoresistance in pancreatic cancer

Bei Hu

Applied & Computational Mathematics & Statistics

Mathematical modeling of tumor growth

Alexandra Jilkine

Applied & Computational Mathematics & Statistics

Mathematical cell biology and cancer evolution

Shahriar Mobashery

Chemistry and Biochemistry

Bioorganic and biochemistry of antibiotic resistance and cancer metastasis

Jeffrey W. Peng

Chemistry and Biochemistry; Physics

NMR methods and biomolecular dynamics

Alex Perkins

Biological Sciences

Infectious disease transmission and control; mathematical, computational, and statistical approaches

David Severson

Biological Sciences

Mosquito Genetics and Genomics

Yongtao Zhang

Applied & Computational Mathematics & Statistics

Application of numerical algorithms to spatio-temporal patterning in biology