Chemical Biology & Molecular Pharmacology
Researchers in the IBMS Chemical Biology and Molecular Pharmacology cluster use the principles of medicinal chemistry to study drugs and drug action, to develop synthetic compounds for exploration as new pharmaceuticals, and to probe and control normal and abnormal biological processes. Expertise includes synthetic chemistry (including combinatorial and natural product synthesis), structure-guided and computational drug design, toxicology and metabolism, and bioassay development. Research emphasizes the integration of biology and chemistry, ensuring that students in the cluster receive strong training in the interface between both fields and learn to exploit chemical diversity as a means to understand biology and advance human health.
Image: SB-3CT, a compound designed and produced in the Mobashery lab, is a potent inhibitor of cancer metastasis.
Contact
Shaun Lee (website>)
Department of Biological Sciences
Contact by email
(574) 631-7197
Participating Faculty
Basar BilgicerChemistry and Biochemistry |
Biophysical chemistry and biomolecular drug design |
Brian BlaggChemistry and Biochemistry |
Mechanisms of protein folding and their contribution to cancer and/or neurodegeneration |
Saurja DasGuptaChemistry and Biochemistry |
RNA structure, function, and evolution, RNA Biology, Origins of life |
Juan Del ValleChemistry and Biochemistry |
Design, chemical synthesis, biological evaluation of modulators of protein-protein interactions, ER stress response inhibitors, non-ribosomal peptide natural products; cancer, neurodegenerative disease, bacterial infections |
Ana Lidia Flores-MirelesBiological Sciences |
Molecular, Cellular, and Immunological Analysis of the Pathogenesis of Catheter-associated Infections |
Kasturi HaldarBiological Sciences |
Understanding disease pathology and developing treatments in rare and neglected diseases |
Shaun LeeBiological Sciences |
Molecular microbiology and biosynthesis of peptide antibiotics |
Christian MelanderChemistry and Biochemistry |
New Approaches for Antibiotic Discovery |
Shahriar MobasheryChemistry and Biochemistry |
Bioorganic and biochemistry of antibiotic resistance and cancer metastasis |
Brittany MorganChemistry and Biochemistry |
Targeting RNA-binding proteins to understand structure, function, and dynamics |
Santiago SchnellBiological Sciences |
Derivation of rate equations and design of experiment protocols to measure the physical constants of enzyme catalyzed and protein aggregation reactions |
Anthony S. SerianniChemistry and Biochemistry |
Biomolecular structure and NMR spectroscopy |
Bradley SmithChemistry and Biochemistry |
Biooganic and supramolecular chemistry; development of new reagents for biomedical imaging |
Richard TaylorChemistry and Biochemistry |
Synthetic organic chemistry; polyketide natural products as chemotherapeutic agents |
Matthew WebberChemistry and Biochemistry |
Engineering improved therapeutics and biomimetic and bio-insprired materials |
Olaf WiestChemistry and Biochemistry |
Computational drug design |